Nihilism concludes that nothing means anything. Stoicism concludes close to the opposite: meaning is real and lives in your own character and choices — the one place fortune cannot reach.
Side by side
Aspect
Stoicism
Nihilism
Meaning
Real, and self-made
There is none
Virtue
The whole point
Pointless
Facing hardship
Meet it with reason
Why bother
The aim
Eudaimonia — flourishing
None
What each one means
Stoicism
In ordinary English, uncomplaining endurance of hardship without showing what it costs. In philosophy, a school founded in Athens and carried on in Rome by Seneca, Epictetus and Marcus Aurelius: virtue is the only real good, we should live in agreement with nature and reason, and peace comes from telling what is in our control from what is not.