Luck requires nothing of you. Serendipity, as coined, requires two things at once: that you were not looking for it, and that you were sharp enough to see it. Drop the sagacity and you have merely renamed luck.
Side by side
Aspect
Serendipity
Luck
Requires alertness
Yes
No
Requires not-seeking
Yes
No
Can be cultivated
Partly
No
Walpole would allow it
Yes
No
What each one means
Serendipity
Finding something valuable you were not looking for. In everyday use that is simply a fortunate accident; in Walpole's stricter original sense it also takes the sagacity to notice what you have stumbled on.